RNF138 Antibody (PACO22321)
- SKU:
- PACO22321
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RNF138 Antibody (PACO22321) |
| Antibody SKU: | PACO22321 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human RNF138. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from MCF-7 cells, using RNF138 antibody. |
| Background: | E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. |
| Synonyms: | E3 ubiquitin-protein ligase RNF138; EC 6.3.2.-; RING finger protein 138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein |
| UniProt Protein Function: | RNF138: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19Chromosomal Location of Human Ortholog: 18q12.1Cellular Component: nucleusMolecular Function: protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin conjugating enzyme bindingBiological Process: double-strand break repair via homologous recombination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WVD3 |
| NCBI GenInfo Identifier: | 74762632 |
| NCBI Gene ID: | 51444 |
| NCBI Accession: | Q8WVD3.1 |
| UniProt Secondary Accession: | Q8WVD3,Q9H8K2, Q9UF87, Q9UKI6, B2RE17 |
| UniProt Related Accession: | Q8WVD3 |
| Molecular Weight: | 17,262 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase RNF138 |
| NCBI Synonym Full Names: | ring finger protein 138 |
| NCBI Official Symbol: | RNF138 |
| NCBI Official Synonym Symbols: | NARF; HSD-4; STRIN; hNARF |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RNF138 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RNF138 |
| UniProt Synonym Protein Names: | Nemo-like kinase-associated RING finger protein |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RNF138 |
| UniProt Entry Name: | RN138_HUMAN |
| Antibodies |
| RNF138 Antibody (PACO04538) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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