Name: RNASET2 Antibody (PACO16983)
SKU: PACO16983
Availability: OutOfStock

Antibody Name:	RNASET2 Antibody (PACO16983)
Antibody SKU:	PACO16983
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human RNASET2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16983(RNASET2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:	This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.
Synonyms:	ribonuclease T2

UniProt Protein Function:	RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Ribonuclease; EC 3.1.27.-; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 6q27 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; lysosome Molecular Function:ribonuclease activity Biological Process: RNA catabolic process Disease: Leukoencephalopathy, Cystic, Without Megalencephaly
NCBI Summary:	This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
UniProt Code:	O00584
NCBI GenInfo Identifier:	20139363
NCBI Gene ID:	8635
NCBI Accession:	O00584.2
UniProt Secondary Accession:	O00584,Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47, B2RDA7, E1P5C3
UniProt Related Accession:	O00584
Molecular Weight:	14,000 Da
NCBI Full Name:	Ribonuclease T2
NCBI Synonym Full Names:	ribonuclease T2
NCBI Official Symbol:	RNASET2
NCBI Official Synonym Symbols:	RNASE6PL; bA514O12.3
NCBI Protein Information:	ribonuclease T2
UniProt Protein Name:	Ribonuclease T2
UniProt Synonym Protein Names:	Ribonuclease 6
Protein Family:	Ribonuclease
UniProt Gene Name:	RNASET2
UniProt Entry Name:	RNT2_HUMAN