RILP Antibody (PACO61121)
- SKU:
- PACO61121
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RILP Antibody (PACO61121) |
| Antibody SKU: | PACO61121 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rab-interacting lysosomal protein (307-385AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61121 diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. |
| Synonyms: | Rab-interacting lysosomal protein, RILP |
| UniProt Protein Function: | RILP: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17p13.3Cellular Component: phagocytic vesicle membrane; protein complex; mitochondrion; lysosome; lysosomal membrane; late endosome membrane; late endosomeMolecular Function: protein binding; Rab GTPase bindingBiological Process: protein transport; endosome to lysosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q96NA2 |
| NCBI GenInfo Identifier: | 93204881 |
| NCBI Gene ID: | 83547 |
| NCBI Accession: | NP_113618.2 |
| UniProt Secondary Accession: | Q96NA2,Q71RE6, Q9BSL3, Q9BYS3, B2RBQ8 |
| UniProt Related Accession: | Q96NA2 |
| Molecular Weight: | 20,726 Da |
| NCBI Full Name: | rab-interacting lysosomal protein |
| NCBI Synonym Full Names: | Rab interacting lysosomal protein |
| NCBI Official Symbol: | RILP |
| NCBI Official Synonym Symbols: | PP10141 |
| NCBI Protein Information: | rab-interacting lysosomal protein |
| UniProt Protein Name: | Rab-interacting lysosomal protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | RILP-like protein |
| UniProt Gene Name: | RILP |
| UniProt Entry Name: | RILP_HUMAN |
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