RIC1 Antibody (PACO46574)
- SKU:
- PACO46574
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RIC1 Antibody (PACO46574) |
| Antibody SKU: | PACO46574 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human RAB6A-GEF complex partner protein 1 protein (951-1233AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO46574 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46574 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. |
| Synonyms: | RAB6A-GEF complex partner protein 1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog), RIC1, CIP150 KIAA1432 |
| UniProt Protein Function: | RIC1: Required for phosphorylation and localization of GJA1. Belongs to the RIC1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Adaptor/scaffoldChromosomal Location of Human Ortholog: 9p24.1Cellular Component: cytosol; membrane; protein complex; trans-Golgi network membraneMolecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activityBiological Process: positive regulation of GTPase activity; retrograde transport, endosome to Golgi |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q4ADV7 |
| NCBI GenInfo Identifier: | 330864713 |
| NCBI Gene ID: | 57589 |
| NCBI Accession: | NP_001129392.2 |
| UniProt Secondary Accession: | Q4ADV7,Q4VXJ8, Q4VXJ9, Q76MT5, Q8N6E0, Q8TEH4, Q9H0A5 Q9H9S1, B2RN24, B7ZM67 |
| UniProt Related Accession: | Q4ADV7 |
| Molecular Weight: | 155,177 Da |
| NCBI Full Name: | RAB6A-GEF complex partner protein 1 isoform b |
| NCBI Synonym Full Names: | RIC1 homolog, RAB6A GEF complex partner 1 |
| NCBI Official Symbol: | RIC1 |
| NCBI Official Synonym Symbols: | CIP150; KIAA1432; bA207C16.1 |
| NCBI Protein Information: | RAB6A-GEF complex partner protein 1 |
| UniProt Protein Name: | RAB6A-GEF complex partner protein 1 |
| UniProt Synonym Protein Names: | Connexin-43-interacting protein of 150 kDa; Protein RIC1 homolog |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RIC1 |
| UniProt Entry Name: | RIC1_HUMAN |
Related Products
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH
otsB Antibody
Overview Product Name:otsB AntibodyProduct Code:PACO64885Size:50µLTarget Names:otsBSpecies Reactivity:Escherichia coli
PCDHA8 Antibody
Overview Product Name:PCDHA8 AntibodyProduct Code:PACO64893Size:50µLTarget Names:PCDHA8Species Reactivity:HumanH