Rhesus Macaque IP 10 Rhesus macaque Recombinant Protein (RPPB1174)

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SKU:
RPPB1174
Product Type:
Recombinant Protein
Species:
Monkey
Uniprot:
Q8MIZ1

Description

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Product Name:Rhesus Macaque IP 10 Rhesus macaque Recombinant Protein
Product Code:RPPB1174
Size:25µg
Species:Rhesus Macaque
Target:IP 10 Rhesus macaque
Synonyms:C-X-C motif chemokine 10, 10 kDa, Gamma-IP10, IP-10, Small-inducible cytokine B10, CXCL10, SCYB10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized IP-10 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:IPLSRTVRCT CISISNQPVN PRSLEKLEII PPSQFCPHVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP
Biological Activity:Determined by its ability to chemoattract human peripheral blood T-Lymphocytes using a concentration range of 10.0-100.0 ng/ml.

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa IP-10. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

IP-10 Rhesus macaque Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.7kDa. The IP-10 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8MIZ1
NCBI GenInfo Identifier:74136347
NCBI Gene ID:574243
NCBI Accession:NP_001028064.1
UniProt Secondary Accession:Q8MIZ1
UniProt Related Accession:Q8MIZ1
Molecular Weight:12.8kD
NCBI Full Name:C-X-C motif chemokine 10
NCBI Synonym Full Names:
NCBI Official Symbol:CXCL10��
NCBI Official Synonym Symbols:
NCBI Protein Information:C-X-C motif chemokine 10
UniProt Protein Name:C-X-C motif chemokine 10
UniProt Synonym Protein Names:10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10
Protein Family:C-X-C motif chemokine
UniProt Gene Name:CXCL10��
UniProt Entry Name:
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