Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (?, β, ?, and ?) with identical extracellular domains.
Product Name:
Rhesus macaque CD155/NECL5 Recombinant Protein (RPES3726)
Product Code:
RPES3726
Size:
10µg
Species:
Rhesus macaque
Expressed Host:
Human Cells
Synonyms:
Poliovirus Receptor, Nectin-Like Protein 5, NECL-5, CD155, PVR, PVS
Accession:
Q0MSE6
Sequence:
Met 1-Asn 343
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Rhesus macaque NECL5 is produced by our Mammalian expression system and the target gene encoding Met 1-Asn 343 is expressed with a 6His tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
35.4 kDa
AP Mol Mass:
50-70 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetHuman CD155/PVR/NECL5 Recombinant Protein Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) fami
system_update_altDatasheetHuman CD155/PVR/NECL5 Recombinant Protein Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) fami