Rhesus macaque B7-H4/VTCN1 Recombinant Protein (RPES3986)
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- SKU:
- RPES3986
- Product Type:
- Recombinant Protein
- Species:
- Monkey
Description
system_update_altDatasheet
Rhesus macaque B7-H4/VTCN1 Recombinant Protein
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
| Product Name: | Rhesus macaque B7-H4/VTCN1 Recombinant Protein (RPES3986) |
| Product Code: | RPES3986 |
| Size: | 10µg |
| Species: | Rhesus macaque |
| Expressed Host: | Human Cells |
| Synonyms: | B7S1, B7x, Vtcn1, B7h.5, B7-H4, B7H4T-cell costimulatory molecule B7x, B7S1VCTN1, B7XPRO1291, FLJ22418, Immune costimulatory protein B7-H4, Protein B7S1, T cell costimulatory molecule B7x, V-set domain containing T cell activation inhibitor 1, V-set domain-containing T-cell activation inhibitor 1 |
| Accession: | F7B770 |
| Sequence: | Phe29-Ala258 |
| Fusion tag: | C-His |
| Activity: | Immobilized Human GFRA1-His(Cat: PKSH033670) at 0.5µg/ml(100 ?l/well) can bind Human GDNF. The ED50 of GDNF is 14.73ug/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Rhesus macaque B7-H4 is produced by our Mammalian expression system and the target gene encoding Phe29-Ala258 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 26.4 kDa |
| AP Mol Mass: | 40-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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