Rhesus macaque B7-H4/VTCN1 Recombinant Protein (RPES3965)

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SKU:
RPES3965
Product Type:
Recombinant Protein
Species:
Monkey

Description

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Rhesus macaque B7-H4/VTCN1 Recombinant Protein

B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.

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