Rhesus macaque AILIM/CD278 Recombinant Protein (RPES3791)

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SKU:
RPES3791
Product Type:
Recombinant Protein
Species:
Monkey

Description

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Rhesus macaque AILIM/CD278 Recombinant Protein

Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige.

Product Name:Rhesus macaque AILIM/CD278 Recombinant Protein (RPES3791)
Product Code:RPES3791
Size:10µg
Species:Rhesus macaque
Expressed Host:Human Cells
Synonyms:Inducible T-cell costimulator,activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1,ICOS
Accession:H9Z062
Sequence:Gly20-Lys140
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Rhesus macaque ICOS is produced by our Mammalian expression system and the target gene encoding Gly20-Lys140 is expressed with a Fc tag at the C-terminus.
Purity:> 90% as determined by reducing SDS-PAGE.
Mol Mass:40.8 kDa
AP Mol Mass:50-60 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS,pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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