RGS22 Antibody (PACO16977)
- SKU:
- PACO16977
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RGS22 Antibody (PACO16977) |
| Antibody SKU: | PACO16977 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RGS22 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, hepg2 cells, Primary antibody: PACO16977(RGS22 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16977(RGS22 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | RGS22 (regulator of G-protein signaling 22), also known as FLJ75004, PRTD-NY2, FLJ40080, MGC102908 or DKFZp434I092, is a novel 1264 amino acid, regulator of G-protein signaling specific to to testis. RGS22 inhibits signal transduction and contains two isoforms as a result of alternative splicing. RGS22 is found in spermatogenic cells and Leydig cells, and may be involved in the translocation of GNA13 from the cytoplasm to the nucleus during spermiogenesis. RGS22 contains two RGS domains: RGS1 and RGS2, and the gene encoding RGS22 maps to human chromosome 8q22.2. |
| Synonyms: | regulator of G-protein signaling 22 |
| UniProt Protein Function: | RGS22: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, RGS; Cancer Testis Antigen (CTA); GAPsChromosomal Location of Human Ortholog: 8q22.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8NE09 |
| NCBI GenInfo Identifier: | 28436875 |
| NCBI Gene ID: | 26166 |
| NCBI Accession: | BC047060 |
| UniProt Secondary Accession: | Q8NE09,Q569L2, Q86Y71, Q9BYZ4, Q9UFN6, A8K944 |
| UniProt Related Accession: | Q8NE09 |
| Molecular Weight: | 145,768 Da |
| NCBI Full Name: | Homo sapiens regulator of G-protein signaling 22, mRNA |
| NCBI Synonym Full Names: | regulator of G-protein signaling 22 |
| NCBI Official Symbol: | RGS22 |
| NCBI Official Synonym Symbols: | CT145; PRTD-NY2 |
| NCBI Protein Information: | regulator of G-protein signaling 22 |
| UniProt Protein Name: | Regulator of G-protein signaling 22 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS22 |
| UniProt Entry Name: | RGS22_HUMAN |
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