Name: RGS19 Antibody (PACO49946)
SKU: PACO49946
Availability: OutOfStock

Antibody Name:	RGS19 Antibody (PACO49946)
Antibody SKU:	PACO49946
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human breast cancer using PACO49946 at dilution of 1:100.
	Immunofluorescent analysis of HepG2 cells using PACO49946 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Immunohistochemistry of paraffin-embedded human liver tissue using PACO49946 at dilution of 1:100.

Background:	Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds to G-α subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-α is inhibited by phosphorylation and palmitoylation of the G-protein.
Synonyms:	Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP), RGS19, GAIP GNAI3IP

UniProt Protein Function:	RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
UniProt Protein Details:	Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density Molecular Function:beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction
NCBI Summary:	G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P49795
NCBI GenInfo Identifier:	1730186
NCBI Gene ID:	10287
NCBI Accession:	P49795.1
UniProt Secondary Accession:	P49795,Q53XN0, Q8TD60, A8K216, E1P5G9,
UniProt Related Accession:	P49795
Molecular Weight:	24,636 Da
NCBI Full Name:	Regulator of G-protein signaling 19
NCBI Synonym Full Names:	regulator of G-protein signaling 19
NCBI Official Symbol:	RGS19
NCBI Official Synonym Symbols:	GAIP; RGSGAIP
NCBI Protein Information:	regulator of G-protein signaling 19
UniProt Protein Name:	Regulator of G-protein signaling 19
UniProt Synonym Protein Names:	G-alpha-interacting protein; GAIP
Protein Family:	Regulator of G-protein signaling
UniProt Gene Name:	RGS19
UniProt Entry Name:	RGS19_HUMAN