Description
Antibody Name: | RGS18 Antibody (PACO49942) |
Antibody SKU: | PACO49942 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Regulator of G-protein signaling 18 protein (28-84AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO49942 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO49942 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. |
Synonyms: | Regulator of G-protein signaling 18 (RGS18), RGS18, RGS13 |
UniProt Protein Function: | RGS18: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.Protein type: GAPs, RGS; GAPsChromosomal Location of Human Ortholog: 1q31.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NS28 |
NCBI GenInfo Identifier: | 18640750 |
NCBI Gene ID: | 64407 |
NCBI Accession: | NP_570138.1 |
UniProt Secondary Accession: | Q9NS28,B2RD23 |
UniProt Related Accession: | Q9NS28 |
Molecular Weight: | 27,582 Da |
NCBI Full Name: | regulator of G-protein signaling 18 |
NCBI Synonym Full Names: | regulator of G-protein signaling 18 |
NCBI Official Symbol: | RGS18 |
NCBI Official Synonym Symbols: | RGS13 |
NCBI Protein Information: | regulator of G-protein signaling 18; regulator of G-protein signalling 13; regulator of G-protein signalling 18 |
UniProt Protein Name: | Regulator of G-protein signaling 18 |
UniProt Synonym Protein Names: | |
Protein Family: | Regulator of G-protein signaling |
UniProt Gene Name: | RGS18 |
UniProt Entry Name: | RGS18_HUMAN |