RGS11 Antibody (PACO16976)
- SKU:
- PACO16976
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RGS11 Antibody (PACO16976) |
| Antibody SKU: | PACO16976 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RGS11 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16976(RGS11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the α subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein α subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. |
| Synonyms: | regulator of G-protein signaling 11 |
| UniProt Protein Function: | RGS11: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; plasma membrane; protein complex Molecular Function:G-protein beta-subunit binding; GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013] |
| UniProt Code: | O94810 |
| NCBI GenInfo Identifier: | 6174947 |
| NCBI Gene ID: | 8786 |
| NCBI Accession: | O94810.2 |
| UniProt Secondary Accession: | O94810,O75883, Q4TT71, Q4TT72, |
| UniProt Related Accession: | O94810 |
| Molecular Weight: | 50,727 Da |
| NCBI Full Name: | Regulator of G-protein signaling 11 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 11 |
| NCBI Official Symbol: | RGS11 |
| NCBI Official Synonym Symbols: | RS11 |
| NCBI Protein Information: | regulator of G-protein signaling 11 |
| UniProt Protein Name: | Regulator of G-protein signaling 11 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS11 |
| UniProt Entry Name: | RGS11_HUMAN |
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