RGS1 Antibody (PACO16972)
- SKU:
- PACO16972
Description
| Antibody Name: | RGS1 Antibody (PACO16972) |
| Antibody SKU: | PACO16972 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human RGS1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: PACO16972(RGS1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16972(RGS1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid, motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G α subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G α subunits to bind G beta/γ subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
| Synonyms: | regulator of G-protein signaling 1 |
| UniProt Protein Function: | RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08116 |
| NCBI GenInfo Identifier: | 229470360 |
| NCBI Gene ID: | 5996 |
| NCBI Accession: | Q08116.3 |
| UniProt Secondary Accession: | Q08116,Q07918, Q9H1W2, B2RDM9, B4DZY0, |
| UniProt Related Accession: | Q08116 |
| Molecular Weight: | 19,134 Da |
| NCBI Full Name: | Regulator of G-protein signaling 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 1 |
| NCBI Official Symbol: | RGS1 |
| NCBI Official Synonym Symbols: | 1R20; BL34; IER1; IR20; HEL-S-87 |
| NCBI Protein Information: | regulator of G-protein signaling 1 |
| UniProt Protein Name: | Regulator of G-protein signaling 1 |
| UniProt Synonym Protein Names: | B-cell activation protein BL34 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS1 |
| UniProt Entry Name: | RGS1_HUMAN |
| Antibodies | ELISA Kits |
| RGS1 Antibody (PACO01426) | Human RGS1 ELISA Kit |
| RGS1 Antibody (PACO02224) | Human Regulator of G-protein signaling 1 (RGS1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Host Species: |
Rabbit |
Isotype: |
IgG |
Applications: |
ELISA |
Applications: |
WB |
Applications: |
IHC |
Antibody Type: |
Polyclonal Antibody |
Conjugation: |
Unconjugated |
