RFX6 Antibody (PACO37726)
- SKU:
- PACO37726
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RFX6 Antibody (PACO37726) |
| Antibody SKU: | PACO37726 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DNA-binding protein RFX6 protein (1-260AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO37726 at dilution of 1:100. |
| Background: | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. |
| Synonyms: | DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1), RFX6, RFXDC1 |
| UniProt Protein Function: | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). |
| UniProt Protein Details: | |
| NCBI Summary: | The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q8HWS3 |
| NCBI GenInfo Identifier: | 258547126 |
| NCBI Gene ID: | 222546 |
| NCBI Accession: | NP_775831.2 |
| UniProt Secondary Accession: | Q8HWS3,Q5T6B3 |
| UniProt Related Accession: | Q8HWS3 |
| Molecular Weight: | 102,461 Da |
| NCBI Full Name: | DNA-binding protein RFX6 |
| NCBI Synonym Full Names: | regulatory factor X6 |
| NCBI Official Symbol: | RFX6 |
| NCBI Official Synonym Symbols: | MTFS; MTCHRS; RFXDC1; dJ955L16.1 |
| NCBI Protein Information: | DNA-binding protein RFX6 |
| UniProt Protein Name: | DNA-binding protein RFX6 |
| UniProt Synonym Protein Names: | Regulatory factor X 6; Regulatory factor X domain-containing protein 1 |
| Protein Family: | DNA-binding protein |
| UniProt Gene Name: | RFX6 |
| UniProt Entry Name: |
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