Product Name:	Retinoid X Receptor gamma Transcription Factor Activity Assay
Product Code:	TFAB00176
Target:	Retinoid X Receptor gamma
Reactivity:	Human, Mouse
Sample Types:	Nuclear or cell lysates

The Assay Genie Retinoid X Receptor gamma transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:	4.5 hours
Detection Method:	Colorimetric 450 nm
Size:	12 x 8-Well Microstrips
Storage:	4°C for 6 months

UniProt Protein Function:	RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily.
UniProt Protein Details:	Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm Molecular Function:protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development
NCBI Summary:	This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
UniProt Code:	P48443
NCBI GenInfo Identifier:	1350913
NCBI Gene ID:	6258
NCBI Accession:	P48443.1
UniProt Secondary Accession:	P48443,Q6IBU7, A6NIP1,
UniProt Related Accession:	P48443
Molecular Weight:	50,871 Da
NCBI Full Name:	Retinoic acid receptor RXR-gamma
NCBI Synonym Full Names:	retinoid X receptor, gamma
NCBI Official Symbol:	RXRG
NCBI Official Synonym Symbols:	RXRC; NR2B3
NCBI Protein Information:	retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3
UniProt Protein Name:	Retinoic acid receptor RXR-gamma
UniProt Synonym Protein Names:	Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
UniProt Gene Name:	RXRG
UniProt Entry Name:	RXRG_HUMAN