Product Name:	Retinoic Acid Receptor beta Transcription Factor Activity Assay
Product Code:	TFAB00172
Target:	Retinoic Acid Receptor beta
Synonyms:	HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon
Reactivity:	Human, Mouse
Sample Types:	Nuclear or cell lysates

The Assay Genie Retinoic Acid Receptor beta transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:	4.5 hours
Detection Method:	Colorimetric 450 nm
Size:	12 x 8-Well Microstrips
Storage:	4°C for 6 months

UniProt Protein Function:	RARB: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Oncoprotein; Nuclear receptor Chromosomal Location of Human Ortholog: 3p24.2 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; protein complex binding; steroid hormone receptor activity; drug binding; retinoic acid receptor activity Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of myelination; glandular epithelial cell development; striatum development; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; positive regulation of neuron differentiation; embryonic gut development; transmembrane transport; negative regulation of apoptosis Disease: Microphthalmia, Syndromic 12
NCBI Summary:	This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:	P10826
NCBI GenInfo Identifier:	17380507
NCBI Gene ID:	5915
NCBI Accession:	P10826.2
UniProt Secondary Accession:	P10826,P12891, Q00989, Q15298, Q9UN48,
UniProt Related Accession:	P10826
Molecular Weight:	Da
NCBI Full Name:	Retinoic acid receptor beta
NCBI Synonym Full Names:	retinoic acid receptor, beta
NCBI Official Symbol:	RARB
NCBI Official Synonym Symbols:	HAP; RRB2; NR1B2; MCOPS12
NCBI Protein Information:	retinoic acid receptor beta; RAR-beta; RAR-epsilon; HBV-activated protein; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2
UniProt Protein Name:	Retinoic acid receptor beta
UniProt Synonym Protein Names:	HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon
Protein Family:	Retinoic acid receptor
UniProt Gene Name:	RARB
UniProt Entry Name:	RARB_HUMAN