REPS2 Antibody (PACO11802)
- SKU:
- PACO11802
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | REPS2 Antibody (PACO11802) |
| Antibody SKU: | PACO11802 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Human REPS2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RALBP1 associated Eps domain containing 2;REPS2;POB1 ; |
| UniProt Protein Function: | REPS2: an adaptor protein involved in growth factor signaling through its influence on the Ral, a small G protein that regulates endocytosis of EGF and insulin receptors. Interacts with DDEF1, paxillin, RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. Forms a ternary complex with activated Ral and RALBP1. Binds epsin 1. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. EGF receptor internalization and signalling is inhibited by increased expression of REPS2. EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2. Two alternatively spliced isoforms have been described. Isoform 2 is down-regulated during progression of prostate cancer. |
| UniProt Protein Details: | Protein type:G protein regulator, misc.; Adaptor/scaffold Chromosomal Location of Human Ortholog: Xp22.2 Molecular Function:protein binding Biological Process: epidermal growth factor receptor signaling pathway; protein complex assembly |
| NCBI Summary: | The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NFH8 |
| NCBI GenInfo Identifier: | 34098575 |
| NCBI Gene ID: | 9185 |
| NCBI Accession: | Q8NFH8.2 |
| UniProt Secondary Accession: | Q8NFH8,O43428, Q5JNZ8, Q8NFI5, A6PWZ6, |
| UniProt Related Accession: | Q8NFH8 |
| Molecular Weight: | 71,405 Da |
| NCBI Full Name: | RalBP1-associated Eps domain-containing protein 2 |
| NCBI Synonym Full Names: | RALBP1 associated Eps domain containing 2 |
| NCBI Official Symbol: | REPS2 |
| NCBI Official Synonym Symbols: | POB1 |
| NCBI Protein Information: | ralBP1-associated Eps domain-containing protein 2 |
| UniProt Protein Name: | RalBP1-associated Eps domain-containing protein 2 |
| UniProt Synonym Protein Names: | Partner of RalBP1; RalBP1-interacting protein 2 |
| Protein Family: | RalBP1-associated Eps domain-containing protein |
| UniProt Gene Name: | REPS2 |
| UniProt Entry Name: | REPS2_HUMAN |
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