Renin Monoclonal Antibody
- SKU:
- CAB24393
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Renin Monoclonal Antibody |
| Product Code: | CAB24393 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63715 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:6000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse kidney, Mouse lung, Mouse ovary, Rat kidney, Rat lung |
| Cellular Location: | Membrane, Secreted |
This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 250-406AA of human Renin (NP_000528.1). |
| Sequence: | QHYEG NFHYI NLIKT GVWQI QMKGV SVGSS TLLCE DGCLA LVDTG ASYIS GSTSS IEKLM EALGA KKRLF DYVVK CNEGP TLPDI SFHLG GKEYT LTSAD YVFQE SYSSK KLCTL AIHAM DIPPP TGPTW ALGAT FIRKF YTEFD RRNNR IGFAL AR |
| Synonyms: | RTD, HNFJ2, ADTKD4 |
| Calculated MW: | 45kDa |
| Observed MW: | 42kDa |
Related Products
IκBα Monoclonal Antibody
Chk1 Monoclonal Antibody
HN1 Monoclonal Antibody
RAB5A Monoclonal Antibody
Palladin Monoclonal Antibody
ATP6V0C Monoclonal Antibody
