Ren1 Antibody (PACO64491)
- SKU:
- PACO64491
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Ren1 Antibody (PACO64491) |
| Antibody SKU: | PACO64491 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:1000-1:5000, IHC:1:100-1:500 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Ren1 protein (65-264AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat Heart tissue, Rat Liver tissue. All lanes: Ren1 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa. |
 | IHC image of PACO64491 diluted at 1:100 and staining in paraffin-embedded rat kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Background: | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Synonyms: | Renin (EC 3.4.23.15) (Angiotensinogenase), Ren1, Ren |
| UniProt Protein Function: | REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.23.15; Secreted, signal peptide; Secreted; Protease Cellular Component: extracellular space; membrane; cytoplasm; intracellular Molecular Function:peptidase activity; insulin-like growth factor receptor binding; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding Biological Process: response to drug; response to cAMP; establishment of blood-nerve barrier; hormone-mediated signaling; drinking behavior; renin-angiotensin regulation of aldosterone production; cell maturation; male gonad development; response to lipopolysaccharide; proteolysis; angiotensin maturation; response to organic substance; beta-amyloid metabolic process; regulation of MAPKKK cascade; regulation of blood pressure; renin-angiotensin regulation of blood volume; mesonephros development; kidney development |
| NCBI Summary: | catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006] |
| UniProt Code: | P08424 |
| NCBI GenInfo Identifier: | 148747255 |
| NCBI Gene ID: | 24715 |
| NCBI Accession: | NP_036774.4 |
| UniProt Secondary Accession: | P08424,Q63497, |
| UniProt Related Accession: | P08424 |
| Molecular Weight: | |
| NCBI Full Name: | renin |
| NCBI Synonym Full Names: | renin |
| NCBI Official Symbol: | Ren |
| NCBI Official Synonym Symbols: | Ren1; RENAA; RATRENAA |
| NCBI Protein Information: | renin; angiotensinogenase; renin 1 structural |
| UniProt Protein Name: | Renin |
| UniProt Synonym Protein Names: | Angiotensinogenase |
| Protein Family: | Protein |
| UniProt Gene Name: | Ren1 |
| UniProt Entry Name: | RENI_RAT |
| ELISA Kits |
| Rat REN (Renin) ELISA Kit (RTFI01481) |
| Rat REN (Renin) CLIA Kit (RTES00023) |
| Rat Renin (Ren1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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