REG3G Antibody (PACO36898)
- SKU:
- PACO36898
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | REG3G Antibody (PACO36898) |
| Antibody SKU: | PACO36898 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Regenerating islet-derived protein 3-γ protein (27-175AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. |
| Synonyms: | Regenerating islet-derived protein 3-γ (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-γ 16.5 kDa form; Regenerating islet-derived protein 3-γ 15 kDa form], REG3G, PAP1B |
| UniProt Protein Function: | REG3G: Might be a stress protein involved in the control of bacterial proliferation. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p12 Cellular Component: cytoplasm; extracellular region Molecular Function:peptidoglycan binding Biological Process: acute-phase response; antimicrobial humoral response; cytolysis in other organism; defense response to Gram-positive bacterium; MyD88-dependent toll-like receptor signaling pathway; negative regulation of keratinocyte differentiation |
| NCBI Summary: | This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q6UW15 |
| NCBI GenInfo Identifier: | 56699413 |
| NCBI Gene ID: | 130120 |
| NCBI Accession: | NP_001008388.1 |
| UniProt Secondary Accession: | Q6UW15,Q3SYE4, Q3SYE6, Q6FH18, A8K980, D6W5J6, |
| UniProt Related Accession: | Q6UW15 |
| Molecular Weight: | |
| NCBI Full Name: | regenerating islet-derived protein 3-gamma isoform 1 preproprotein |
| NCBI Synonym Full Names: | regenerating family member 3 gamma |
| NCBI Official Symbol: | REG3G |
| NCBI Official Synonym Symbols: | PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III |
| NCBI Protein Information: | regenerating islet-derived protein 3-gamma |
| UniProt Protein Name: | Regenerating islet-derived protein 3-gamma |
| UniProt Synonym Protein Names: | Pancreatitis-associated protein 1B; PAP-1B |
| Protein Family: | Regenerating islet-derived protein |
| UniProt Gene Name: | REG3G |
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