REG3A Monoclonal Antibody (CPAB0734)

Name: REG3A Monoclonal Antibody (CPAB0734)
SKU: CPAB0734
Availability: OutOfStock

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Description

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Immunology Antibodies 1

Immunology Antibodies 2

system_update_alt Datasheet Overview

OverviewProduct Name:GSDMC Monoclonal AntibodyProduct Code:CAB21213Reactivity:Human, Mouse, RatApplications:Western blotting

Purification Method:	Immunoaffinity chromatography on a column with immobilized recombinant human REG3A.
Isotype:
Background:	Pancreatitis-associated protein (PAP) is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro, its definitive biological function in vivo is not clear. Using antisepse oligonucleotides, inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis, PAP released by the pancreas could mediate lung inflammation through induction of hepatic TNF- alpha expression and subsequent increase in circulating TNF-alpha. PAP is activated in primary liver cancers. In normal liver, the protein is undetectable in normal mature hepatocytes and found only in some ductular cells, representing potential hepatic progenitor cells. PAP can be considered hepatic cytokine that combines mitogenic and anti-apoptotic functions regarding hepatocytes, and consequently acts as a growth factor in vivo to enhance liver regeneration.
Synonyms:	Regenerating islet-derived protein 3 alpha, Reg III-alpha, Pancreatitis-associated protein 1, REG3A, HIP, PAP, PAP1, REG3, INGAP, PAP-H, PBCGF, REG-III.
Storage Buffer: