Recombinant VEGF Monoclonal Antibody (CPAB0081)

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SKU:
CPAB0081
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human

Description

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Product Name:Recombinant VEGF Antibody
Product Sku:CPAB0081
Size:1mg
Host Species:
Immunogen:
Clone:
Reactivity:Human
Applications:
Purification Method:
Isotype:
Background:Vascular endothelial growth factoris an important signaling proteininvolved in both vasculogenesisand angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophagemigration, neurons, cancer cells, kidney epithelial cells ).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesisand cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.
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