Name: Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-10His)
SKU: RPES6791
Availability: OutOfStock

Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-10His)

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RPES6791

Description

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Additional Information

Product Type:	Recombinant Protein
Species:	Monkey

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OverviewProduct Name:Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc)Product Code:RPES6792Size:10µgSpecies:

OverviewProduct Name:Recombinant Mouse Angiotensin-Converting Enzyme 2/ACE-2 (C-10His)Product Code:RPES6669Size:10µgSpecies:Mouse

OverviewProduct Name:Recombinant Rhesus Macaque Angiopoietin-2/ANG2 (C-Fc)Product Code:RPES6789Size:10µgSpecies:Rhesus Macaque

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OverviewProduct Name:Recombinant Rhesus Macaque CD79B/B29 (C-Fc)Product Code:RPES6782Size:10µgSpecies:Rhesus Macaque

Mol Mass:	85.1 kDa
AP Mol Mass:	90-120 kDa
Tag:	C-10His
Purity:	> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:	< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:	Immobilized Rhesus Macaque ACE-2-Hisat 5μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc. The ED50 of Recombinant 2019-nCoV S Protein RBD-SD1-mFc is 16.8 ng/ml.

Sequence:	Gln18-Val739
Accession:	ACI04564.1
Storage:	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation:	Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 150mM NaCl, 1mM ZnCl2, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the
Reconstitution:	Not Applicable
Background:	Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.