Recombinant Human/Cynomolgus CD28/TP44 (N-His)
- SKU:
- RPES6192
- Product Type:
- Recombinant Protein
- Species:
- Human
- Species:
- Monkey
Description
| Product Name: | Recombinant Human/Cynomolgus CD28/TP44 (N-His) |
| Product Code: | RPES6192 |
| Size: | 10µg |
| Species: | Human/Cynomolgus |
| Expression Host: | HEK293 Cells |
| Synonyms: | CD28, CD28 antigen, CD28 molecule, T-cell-specific surface glycoprotein CD28, Tp44, TP44 |
| Mol Mass: | 16.7 kDa |
| AP Mol Mass: | 30-40 kDa |
| Tag: | N-6His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Bio Activity: | Immobilized Human/Cynomolgus CD28-His at 2μg/ml (100 μl/well) can bind Anti-CD28 mAb. The ED50 of Anti-CD28 mAb is 15.3 ng/ml. |
| Sequence: | Asn19-Pro152 |
| Accession: | P10747 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the print |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. |
Related Products
Human CD28/TP44 Recombinant Protein (RPES5016)
system_update_altDatasheetHuman CD28/TP44 Recombinant Protein T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobu
Human CD28/TP44 Recombinant Protein (RPES5104)
Growth Factors & Cytokines Recombinant Proteins
system_update_altDatasheetHuman CD28/TP44 Recombinant Protein T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglo
Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated
OverviewProduct Name:Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) BiotinylatedProduct Code:RPES6298Size:20µgSpecies:Human/Cy
Mouse CD28/TP44 Recombinant Protein (RPES0536)
system_update_altDatasheetMouse CD28/TP44 Recombinant Protein T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that p
Mouse CD28/TP44 Recombinant Protein (RPES4735)
system_update_altDatasheetMouse CD28/TP44 Recombinant Protein CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and s