Recombinant HER2 Monoclonal Antibody (CPAB0212)
- SKU:
- CPAB0212
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
Description
system_update_alt Datasheet
| Product Name: | Recombinant HER2 Antibody |
| Product Sku: | CPAB0212 |
| Size: | 1mg |
| Host Species: | |
| Immunogen: | |
| Clone: | |
| Reactivity: | Human |
| Applications: |
| Purification Method: | |
| Isotype: | |
| Background: | HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
| Synonyms: | |
| Storage Buffer: |
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