RCAN2 Antibody (PACO52330)
- SKU:
- PACO52330
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RCAN2 Antibody (PACO52330) |
| Antibody SKU: | PACO52330 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Calcipressin-2 protein (88-197AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: RCAN2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 22, 28 kDa. Observed band size: 22 kDa. |
 | Immunofluorescent analysis of A549 cells using PACO52330 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO52330 at dilution of 1:100. |
| Background: | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. |
| Synonyms: | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4), RCAN2, DSCR1L1 ZAKI4 |
| UniProt Protein Function: | RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p12.3Cellular Component: cytoplasmMolecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q14206 |
| NCBI GenInfo Identifier: | 158958336 |
| NCBI Gene ID: | 10231 |
| NCBI Accession: | Q14206.3 |
| UniProt Secondary Accession: | Q14206,Q5VWF7, Q5VWF8, Q8N116, A6ND07, B3KR46 |
| UniProt Related Accession: | Q14206 |
| Molecular Weight: | 27,289 Da |
| NCBI Full Name: | Calcipressin-2 |
| NCBI Synonym Full Names: | regulator of calcineurin 2 |
| NCBI Official Symbol: | RCAN2 |
| NCBI Official Synonym Symbols: | CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1 |
| NCBI Protein Information: | calcipressin-2 |
| UniProt Protein Name: | Calcipressin-2 |
| UniProt Synonym Protein Names: | Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4 |
| Protein Family: | Calcipressin |
| UniProt Gene Name: | RCAN2 |
| UniProt Entry Name: | RCAN2_HUMAN |
| Antibodies |
| RCAN2 Antibody (PACO11777) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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