RCAN2 Antibody (PACO19177)
- SKU:
- PACO19177
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RCAN2 Antibody (PACO19177) |
| Antibody SKU: | PACO19177 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human RCAN2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19177(RCAN2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Synonyms: | regulator of calcineurin 2 |
| UniProt Protein Function: | RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p12.3Cellular Component: cytoplasmMolecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q14206 |
| NCBI GenInfo Identifier: | 158958336 |
| NCBI Gene ID: | 10231 |
| NCBI Accession: | Q14206.3 |
| UniProt Secondary Accession: | Q14206,Q5VWF7, Q5VWF8, Q8N116, A6ND07, B3KR46 |
| UniProt Related Accession: | Q14206 |
| Molecular Weight: | 27,289 Da |
| NCBI Full Name: | Calcipressin-2 |
| NCBI Synonym Full Names: | regulator of calcineurin 2 |
| NCBI Official Symbol: | RCAN2 |
| NCBI Official Synonym Symbols: | CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1 |
| NCBI Protein Information: | calcipressin-2 |
| UniProt Protein Name: | Calcipressin-2 |
| UniProt Synonym Protein Names: | Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4 |
| Protein Family: | Calcipressin |
| UniProt Gene Name: | RCAN2 |
| UniProt Entry Name: | RCAN2_HUMAN |
| Antibodies |
| RCAN2 Antibody (PACO11777) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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