RBM38 Antibody (PACO52818)
- SKU:
- PACO52818
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RBM38 Antibody (PACO52818) |
| Antibody SKU: | PACO52818 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human RNA-binding protein 38 protein (1-239AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO52818 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO52818 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. |
| Synonyms: | RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4), RBM38, RNPC1 SEB4 |
| UniProt Protein Function: | CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: heterophilic cell adhesion; axon guidance; intercellular junction assembly and maintenance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H0Z9 |
| NCBI GenInfo Identifier: | 34577107 |
| NCBI Gene ID: | 55544 |
| NCBI Accession: | NP_059965 |
| UniProt Secondary Accession: | Q9H0Z9,Q9H0Z9 |
| UniProt Related Accession: | Q9H0Z9 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | RNA-binding protein 38 isoform a |
| NCBI Synonym Full Names: | RNA binding motif protein 38 |
| NCBI Official Symbol: | RBM38 |
| NCBI Official Synonym Symbols: | RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2 |
| NCBI Protein Information: | RNA-binding protein 38 |
| UniProt Protein Name: | Cadherin-4 |
| UniProt Synonym Protein Names: | Retinal cadherin |
| Protein Family: | |
| UniProt Gene Name: | CDH4 |
| UniProt Entry Name: | CADH4_HUMAN |
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