RbAp46/RBBP7 Monoclonal Antibody
- SKU:
- CAB22274
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | RbAp46/RBBP7 Monoclonal Antibody |
| Product Code: | CAB22274 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55384 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:20000, IHC-P 1:100-1:500, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293F, HeLa, Mouse placenta, NIH/3T3 |
| Cellular Location: | Nucleus |
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RbAp46/RBBP7 (NP_002884.1). |
| Sequence: | MASKE MFEDT VEERV INEEY KIWKK NTPFL YDLVM THALQ WPSLT VQWLP EVTKP EGKDY ALHWL VLGTH TSDEQ NHLVV ARVHI PNDDA QFDAS HCDSD KGEFG GFGSV TGKIE CEIKI NHEGE VNRAR YMPQN PHIIA TKTPS SDVLV FDYTK HPAKP DPSGE CNPDL RLRGH QKEGY GLSWN SNLSG HLLSA SDDHT VCLWD INAGP KEGKI VDAKA IFTGH SAVVE |
| Synonyms: | RbAp46 |
| Calculated MW: | 48kDa |
| Observed MW: | 50kDa |
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