RB Monoclonal Antibody
- SKU:
- CAB22663
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | RB Monoclonal Antibody |
| Product Code: | CAB22663 |
| Reactivity: | Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57809 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human RB1 (NP_000312.2). |
| Sequence: | DSIIV FYNSV FMQRL KTNIL QYAST RPPTL SPIPH IPRSP YKFPS SPLRI PGGNI YISPL KSPYK ISEGL PTPTK MTPRS RILVS IGESF GTSEK FQKIN Q |
| Synonyms: | RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1 |
| Calculated MW: | 106kDa |
| Observed MW: | Refer to figures |
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