Developmental Biology Recombinant Proteins
Rat TrkB/NTRK2 Recombinant Protein (RPES0133)
- SKU:
- RPES0133
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Research Area:
- Developmental Biology
Description
Rat TrkB/NTRK2 Recombinant Protein
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Rat TrkB/NTRK2 Recombinant Protein (RPES0133) |
| Product Code: | RPES0133 |
| Size: | 20µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | NTRK2,Trkb |
| Accession: | Q63604-Isoform T1 |
| Sequence: | Met1-His429 |
| Fusion tag: | C-His |
| Activity: | Measured by its binding ability in a functional ELISA.Immobilized rat NTRK2-His at 10 µg/ml (100 ?l/well) can bind biotinylated mouse BDNF , The EC50 of biotinylated mouse BDNF is 12.2-28.6 ng/ml. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method |
| Protein Construction: | A DNA sequence encoding the rat NTRK2 (Q63604-Isoform T1) (Met1-His429) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 47.1 kDa |
| AP Mol Mass: | 67 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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