Rat Tie2/TEK Recombinant Protein (RPES1128)
- SKU:
- RPES1128
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
system_update_altDatasheet
Rat Tie2/TEK Recombinant Protein
TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
| Product Name: | Rat Tie2/TEK Recombinant Protein (RPES1128) |
| Product Code: | RPES1128 |
| Size: | 100µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Tie-2,Tie2 |
| Accession: | NP_001099207.1 |
| Sequence: | Met 4-Leu 743 |
| Fusion tag: | C-Fc |
| Activity: | 1. Measured by its binding ability in a functional ELISA.2. Immobilized S1h-3C-mANGPT2 at 10 µg/mL (100 ?L/well) can bind ratTEK-Fc.The EC50 of ratTEK-Fc is 0.26-0.62µg/mL. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method |
| Protein Construction: | A DNA sequence encoding the rat TEK (NP_001099207.1) extracellular domain (Met 4-Leu 743) was fused with the Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 108 kDa |
| AP Mol Mass: | 120-130 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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