Chemokines Recombinant Proteins

Rat Rantes Recombinant Protein (RPPB1244)

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SKU:
RPPB1244
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P50231
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat Rantes Recombinant Protein
Product Code:RPPB1244
Size:20µg
Species:Rat
Target:Rantes
Synonyms:Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Solubility:It is recommended to reconstitute the lyophilized Rantes in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Rat Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Biological Activity:The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites.

Rantes Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton. The Rat Rantes is purified by proprietary chromatographic techniques.

UniProt Protein Function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
UniProt Protein Details:
NCBI Summary:may play a role in cellular response to viral infection in testicular somatic cells [RGD, Feb 2006]
UniProt Code:P50231
NCBI GenInfo Identifier:1711393
NCBI Gene ID:81780
NCBI Accession:P50231.1
UniProt Secondary Accession:P50231
UniProt Related Accession:P50231
Molecular Weight:10,170 Da
NCBI Full Name:C-C motif chemokine 5
NCBI Synonym Full Names:chemokine (C-C motif) ligand 5
NCBI Official Symbol:Ccl5��
NCBI Official Synonym Symbols:Scya5; Rantes��
NCBI Protein Information:C-C motif chemokine 5
UniProt Protein Name:C-C motif chemokine 5
UniProt Synonym Protein Names:SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES
Protein Family:C-C motif chemokine
UniProt Gene Name:Ccl5��
UniProt Entry Name:CCL5_RAT
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system_update_altDatasheetRat CCL5/RANTES Recombinant Protein C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its abili