Growth Factors & Cytokines Recombinant Proteins

Rat Prolactin Recombinant Protein (RPPB0875)

(No reviews yet) Write a Review
SKU:
RPPB0875

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat Prolactin Recombinant Protein
Product Code:RPPB0875
Size:50µg
Species:Rat
Target:Prolactin
Synonyms:Mammotropin, Luterotropic hormone, Lutetropin, PRL.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl.
Solubility:It is recommended to reconstitute the lyophilized Prolactin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prolactin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Val-Cys
Biological Activity:The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065 ng/ml corresponding to a specific activity of 15,400,000 Units/mg.

Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation.

Prolactin Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6 kDa. The Prolactin is purified by proprietary chromatographic techniques.

UniProt Protein Function:prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.
UniProt Protein Details:

Protein type:Secreted; Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide

Cellular Component: extracellular region; secretory granule

Molecular Function:prolactin receptor binding; hormone activity

Biological Process: response to drug; circadian rhythm; lactation; maternal behavior; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; response to organic cyclic substance; response to estradiol stimulus; cellular response to hormone stimulus; response to ethanol; regulation of JAK-STAT cascade; ovulation cycle; mammary gland development; positive regulation of cell proliferation; parturition; regulation of ossification; multicellular organismal response to stress; positive regulation of epithelial cell proliferation; response to nutrient; STAT protein nuclear translocation

NCBI Summary:induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]
UniProt Code:P01237
NCBI GenInfo Identifier:130938
NCBI Gene ID:24683
NCBI Accession:P01237.1
UniProt Secondary Accession:P01237,P70520,
UniProt Related Accession:P01237
Molecular Weight:25,753 Da
NCBI Full Name:Prolactin
NCBI Synonym Full Names:prolactin
NCBI Official Symbol:Prl��
NCBI Official Synonym Symbols:PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1��
NCBI Protein Information:prolactin; prolactin family 1, subfamily a, member 1
UniProt Protein Name:Prolactin
Protein Family:Prolactin
UniProt Gene Name:Prl��
UniProt Entry Name:PRL_RAT
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P01237
Research Area:
Growth Factors & Cytokines
View AllClose

Related Products