Hormones Recombinant Proteins

Rat Procalcitonin Recombinant Protein (RPPB5752)

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RPPB5752

Description

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Product Name:Rat Procalcitonin Recombinant Protein
Product Code:RPPB5752
Size:10µg
Species:Rat
Target:Procalcitonin
Synonyms:Calcitonin, Calca, Calc.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:Procalcitonin was filtered (0.4�m) and lyophilized in 20mM TRIS and 50mM NaCl, pH 8.0.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Procalcitonin is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASVPLRSTLESS PGMATLSEEE ARLLAALVQN YMQMKVRELE QEEEQEAEGS SLDSPRSKRC GNLSTCMLGT YTQDLNKFHT FPQTSIGVGA PGKKRDMAKD LETNHHPYFG N

Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.

Procalcitonin Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val26-Asn136) containing 121 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 13.6kDa.

UniProt Protein Function:CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q35

Cellular Component: axon; cell soma; cytoplasm; extracellular region; extracellular space; intracellular; neuron projection; nucleus; terminal button

Molecular Function:calcitonin receptor binding; identical protein binding; neuropeptide hormone activity; protein complex binding; receptor binding

Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuromuscular junction development; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP metabolic process; positive regulation of cell adhesion; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart contraction; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; vasculature development; vasodilation; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure

NCBI Summary:an inhibitor of lactotroph function and a potent vasodilator [RGD, Feb 2006]
UniProt Code:P01257
NCBI GenInfo Identifier:8567332
NCBI Gene ID:24241
NCBI Accession:NP_059034.1
UniProt Related Accession:P01257,P01256
Molecular Weight:13,948 Da
NCBI Full Name:calcitonin gene-related peptide 1 isoform Calca preproprotein
NCBI Synonym Full Names:calcitonin-related polypeptide alpha
NCBI Official Symbol:Calca��
NCBI Official Synonym Symbols:CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin��
NCBI Protein Information:calcitonin gene-related peptide 1
UniProt Protein Name:Calcitonin
Protein Family:Calcitonin
UniProt Gene Name:Calca��
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Additional Information

Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P01257
Research Area:
Hormones
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