Hormones Recombinant Proteins
Rat Procalcitonin Recombinant Protein (RPPB5752)
- SKU:
- RPPB5752
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P01257
- Research Area:
- Hormones
Description
| Product Name: | Rat Procalcitonin Recombinant Protein |
| Product Code: | RPPB5752 |
| Size: | 10µg |
| Species: | Rat |
| Target: | Procalcitonin |
| Synonyms: | Calcitonin, Calca, Calc. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Procalcitonin was filtered (0.4�m) and lyophilized in 20mM TRIS and 50mM NaCl, pH 8.0. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Procalcitonin is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASVPLRSTLESS PGMATLSEEE ARLLAALVQN YMQMKVRELE QEEEQEAEGS SLDSPRSKRC GNLSTCMLGT YTQDLNKFHT FPQTSIGVGA PGKKRDMAKD LETNHHPYFG N |
Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.
Procalcitonin Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val26-Asn136) containing 121 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 13.6kDa.
| UniProt Protein Function: | CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1q35 Cellular Component: axon; cell soma; cytoplasm; extracellular region; extracellular space; intracellular; neuron projection; nucleus; terminal button Molecular Function:calcitonin receptor binding; identical protein binding; neuropeptide hormone activity; protein complex binding; receptor binding Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuromuscular junction development; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP metabolic process; positive regulation of cell adhesion; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart contraction; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; vasculature development; vasodilation; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure |
| NCBI Summary: | an inhibitor of lactotroph function and a potent vasodilator [RGD, Feb 2006] |
| UniProt Code: | P01257 |
| NCBI GenInfo Identifier: | 8567332 |
| NCBI Gene ID: | 24241 |
| NCBI Accession: | NP_059034.1 |
| UniProt Related Accession: | P01257,P01256 |
| Molecular Weight: | 13,948 Da |
| NCBI Full Name: | calcitonin gene-related peptide 1 isoform Calca preproprotein |
| NCBI Synonym Full Names: | calcitonin-related polypeptide alpha |
| NCBI Official Symbol: | Calca�� |
| NCBI Official Synonym Symbols: | CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin�� |
| NCBI Protein Information: | calcitonin gene-related peptide 1 |
| UniProt Protein Name: | Calcitonin |
| Protein Family: | Calcitonin |
| UniProt Gene Name: | Calca�� |
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