Enzymes Recombinant Proteins

Rat PRDX2 Recombinant Protein (RPPB2178)

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RPPB2178

Description

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Product Name:Rat PRDX2 Recombinant Protein
Product Code:RPPB2178
Size:20µg
Species:Rat
Target:PRDX2
Synonyms:Peroxiredoxin-2, Prdx2, Prdx, Thiol-specific antioxidantprotein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxidereductase 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PRDX2protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4), 10%glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMASGNA HIGKPAPDFT GTAVVDGAFK EIKLSDYRGK YVVLFFYPLDFTFVCPTEII AFSDHAEDFR KLGCEVLGVS VDSQFTHLAW INTPRKEGGL GPLNIPLLAD VTKSLSQNYGVLKNDEGIAY RGLFIIDAKG VLRQITVNDL PVGRSVDEALRLVQAFQYTD EHGEVCPAGW KPGSDTIKPN VDDSKEYFSK HN

PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX2 has proliferative effect in cancer development or progression.If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer's or DNA damage leading to cancer.

PRDX2 Rat Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 222 amino acids (1-198 a.a) andhaving a molecular mass of 24.3kDa.PRDX2 is fused to a 24 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified.
UniProt Protein Details:

Protein type:EC 1.11.1.15; Oxidoreductase

Cellular Component: cytosol; mitochondrion; myelin sheath

Molecular Function:antioxidant activity; peroxidase activity; peroxiredoxin activity; thioredoxin peroxidase activity

Biological Process: activation of MAPK activity; homeostasis of number of cells; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; inhibition of NF-kappaB transcription factor; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neuron apoptosis; negative regulation of T cell differentiation; positive regulation of blood coagulation; regulation of apoptosis; regulation of hydrogen peroxide metabolic process; removal of superoxide radicals; respiratory burst during acute inflammatory response; response to lipopolysaccharide; response to oxidative stress; T cell proliferation; thymus development

NCBI Summary:protective enzyme against oxidative damage by cellular reactive sulfur species [RGD, Feb 2006]
UniProt Code:P35704
NCBI GenInfo Identifier:8394432
NCBI Gene ID:29338
NCBI Accession:NP_058865.1
UniProt Secondary Accession:P35704,Q6PDV3,
UniProt Related Accession:P35704
Molecular Weight:21,784 Da
NCBI Full Name:peroxiredoxin-2
NCBI Synonym Full Names:peroxiredoxin 2
NCBI Official Symbol:Prdx2��
NCBI Official Synonym Symbols:Tdpx1��
NCBI Protein Information:peroxiredoxin-2
UniProt Protein Name:Peroxiredoxin-2
UniProt Synonym Protein Names:Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
Protein Family:Peroxiredoxin
UniProt Gene Name:Prdx2��
UniProt Entry Name:PRDX2_RAT
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Additional Information

Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P35704
Research Area:
Enzymes
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