Rat PD-L1 Recombinant Protein (C-His) (RPES4268)
- SKU:
- RPES4268
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
Rat PD-L1 Recombinant Protein (C-His)
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
| Product Name: | Rat PD-L1 Recombinant Protein (C-His) (RPES4268) |
| Product Code: | RPES4268 |
| Size: | 10µg |
| Species: | Rat |
| Expressed Host: | Human Cells |
| Synonyms: | B7-H,B7-H1,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1 |
| Accession: | D4AE25 |
| Sequence: | Ala18-Thr238 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Rat PD-L1 is produced by our Mammalian expression system and the target gene encoding Ala18-Thr238 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 26.1 kDa |
| AP Mol Mass: | 40-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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