Chemokines Recombinant Proteins

Rat MCP 3 Recombinant Protein (RPPB1196)

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SKU:
RPPB1196
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
Q9QXY8
Research Area:
Chemokines

Description

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Product Name:Rat MCP 3 Recombinant Protein
Product Code:RPPB1196
Size:10µg
Species:Rat
Target:MCP 3
Synonyms:C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, MCP-3, Small-inducible cytokine A7, Ccl7, Mcp3, Scya7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:MCP-3 protein was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, 300mM NaCl, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized MCP-3 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution�MCP3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:QPDGTNSSTC CYVKKQKIPK RNLKSYRKIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTS TPKP
Biological Activity:Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-300.0 ng/ml.

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1).

MCP-3 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8.5kDa.The MCP-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space

Molecular Function:CCR chemokine receptor binding; CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity; heparin binding

Biological Process: cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of inflammatory response; regulation of cell shape; response to gamma radiation

UniProt Code:Q9QXY8
NCBI GenInfo Identifier:9087193
NCBI Gene ID:287561
NCBI Accession:Q9QXY8.1
UniProt Related Accession:Q9QXY8
Molecular Weight:10,906 Da
NCBI Full Name:C-C motif chemokine 7
NCBI Synonym Full Names:C-C motif chemokine ligand 7
NCBI Official Symbol:Ccl7��
NCBI Protein Information:C-C motif chemokine 7
UniProt Protein Name:C-C motif chemokine 7
UniProt Synonym Protein Names:Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; Small-inducible cytokine A7
Protein Family:C-C motif chemokine
UniProt Gene Name:Ccl7��
UniProt Entry Name:CCL7_RAT
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