Neurotrophins Recombinant Proteins

Rat MANF Recombinant Protein (RPPB0747)

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SKU:
RPPB0747
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P0C5H9
Research Area:
Neurotrophins

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat MANF Recombinant Protein
Product Code:RPPB0747
Size:20µg
Species:Rat
Target:MANF
Synonyms:Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, Manf, Armet.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized MANF in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MANF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MANF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIEEELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGEMCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Biological Activity:The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 10�g/ml, corresponding to a specific activity of >100 IU/mg.

MANF is a 20kDa protein which belongs to the ARMET family. MANF was originally known as an arginine-rich region protein which was extremely mutated in a large number of tumors. MANF Expression is induced during ER stress, signifying that MANF takes part in protein quality control during ER stress.

MANF Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18.2kDa.

UniProt Protein Function:ARMET: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Belongs to the ARMET family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Cellular Component: extracellular space; perinuclear region of cytoplasm; endoplasmic reticulum; nucleus

Molecular Function:growth factor activity

Biological Process: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure; response to unfolded protein

UniProt Code:P0C5H9
NCBI GenInfo Identifier:564365478
NCBI Gene ID:315989
NCBI Accession:XP_006243837.1
UniProt Related Accession:P0C5H9
Molecular Weight:20,388 Da
NCBI Full Name:mesencephalic astrocyte-derived neurotrophic factor isoform X1
NCBI Synonym Full Names:mesencephalic astrocyte-derived neurotrophic factor
NCBI Official Symbol:Manf��
NCBI Official Synonym Symbols:Armet��
NCBI Protein Information:mesencephalic astrocyte-derived neurotrophic factor
UniProt Protein Name:Mesencephalic astrocyte-derived neurotrophic factor
UniProt Synonym Protein Names:Arginine-rich protein; Protein ARMET
Protein Family:MANF/CDNF-like protein
UniProt Gene Name:Manf��
UniProt Entry Name:MANF_RAT
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