Growth Factors & Cytokines Recombinant Proteins
Rat M CSF Recombinant Protein (RPPB0756)
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- SKU:
- RPPB0756
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q8JZQ0
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Rat M CSF Recombinant Protein |
| Product Code: | RPPB0756 |
| Size: | 10µg |
| Species: | Rat |
| Target: | M CSF |
| Synonyms: | Macrophage colony-stimulating factor 1, CSF-1, MCSF, Csf1, Csfm. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a sterile filtered aqueous solution containing 10mM Na3PO4, pH 7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized MCSF in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized MCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCSF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF� FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP |
| Biological Activity: | The activity as determined by dose-dependent induction of M-NFS-60 cell proliferation is 1.65 ng/ml. This corresponds to an expected specific activity of 6.1x105 units/mg. |
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
Macrophage Colony Stimulating Factor Rat Recombinant produced in E.coli is a non-glycosylated homodimer, containing 2 x 155 amino acids and having a total molecular mass of 36.2 kDa.MCSF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| NCBI Summary: | plays a role in macrophage formation; involved in osteoclastogenesis and endochondral ossification [RGD, Feb 2006] |
| UniProt Code: | Q8JZQ0 |
| NCBI GenInfo Identifier: | 28201782 |
| NCBI Gene ID: | 78965 |
| NCBI Accession: | Q8JZQ0.1 |
| UniProt Related Accession: | Q8JZQ0 |
| Molecular Weight: | 62,187 Da |
| NCBI Full Name: | Macrophage colony-stimulating factor 1 |
| NCBI Synonym Full Names: | colony stimulating factor 1 |
| NCBI Official Symbol: | Csf1�� |
| NCBI Protein Information: | macrophage colony-stimulating factor 1 |
| UniProt Protein Name: | Macrophage colony-stimulating factor 1 |
| Protein Family: | Macrophage colony-stimulating factor |
| UniProt Gene Name: | Csf1�� |
| UniProt Entry Name: | CSF1_RAT |
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