Growth Factors & Cytokines Recombinant Proteins

Rat M CSF Recombinant Protein (RPPB0755)

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SKU:
RPPB0755
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
Q8JZQ0
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat M CSF Recombinant Protein
Product Code:RPPB0755
Size:10µg
Species:Rat
Target:M CSF
Synonyms:CSF-1, Lanimostim, MCSF, MGC31930, M-CSF.
Source:HEK293 Cells
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The recombinant�MCSF was lyophilized after extensive dialysis against PBS.
Solubility:It is recommended to reconstitute the�MCSF in sterile PBS not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCSF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Biological Activity:The ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of mouse M-NFS-60 cells.

Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.

MCSF Rat Recombinant produced in HEK-293 cells is a secreted protein (amino acids Glu33-Arg254). M-CSF is disulfide-linked homodimer containing 2 x 222 a.a chains.

UniProt Protein Function:Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
NCBI Summary:plays a role in macrophage formation; involved in osteoclastogenesis and endochondral ossification [RGD, Feb 2006]
UniProt Code:Q8JZQ0
NCBI GenInfo Identifier:28201782
NCBI Gene ID:78965
NCBI Accession:Q8JZQ0.1
UniProt Related Accession:Q8JZQ0
Molecular Weight:62,187 Da
NCBI Full Name:Macrophage colony-stimulating factor 1
NCBI Synonym Full Names:colony stimulating factor 1
NCBI Official Symbol:Csf1��
NCBI Protein Information:macrophage colony-stimulating factor 1
UniProt Protein Name:Macrophage colony-stimulating factor 1
Protein Family:Macrophage colony-stimulating factor
UniProt Gene Name:Csf1��
UniProt Entry Name:CSF1_RAT
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