Growth Factors & Cytokines Recombinant Proteins

Rat M-CSF/CSF1 Recombinant Protein (RPES0456)

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SKU:
RPES0456
Product Type:
Recombinant Protein
Species:
Rat
Research Area:
Growth Factors & Cytokines

Description

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Rat M-CSF/CSF1 Recombinant Protein

Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. MCSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It is involved in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development which for normal male and female fertility. It promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. MCSF also plays a role in lipoprotein clearance.

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