Chemokines Recombinant Proteins
Rat Lymphotactin Recombinant Protein (RPPB1184)
- SKU:
- RPPB1184
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P51672
- Research Area:
- Chemokines
Description
| Product Name: | Rat Lymphotactin Recombinant Protein |
| Product Code: | RPPB1184 |
| Size: | 100µg |
| Species: | Rat |
| Target: | Lymphotactin |
| Synonyms: | XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized XCL1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Lymphotactin should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | VGTEVLQESI CVSLRTQRLP VQKIKTYTIK EGAMRAVIFV TKRGLRICAD PQAKWVKTAI KTVDGRASAS KSKAETIPTQ AQRSASTAVT LTG |
| Biological Activity: | The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells < 100 ng/ml, corresponding to a specific activity of > 1.0 � 104 IU/mg. |
XCL1 is a small cytokine belongs to the XC chemokine family that is also known as lymphotactin. XCL1 is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to XCL2, whose gene is found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.
Lymphotactin (XCL1) Rat Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of approximately 10.0kDa.Lymphotactin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 13q23 Cellular Component: extracellular space Molecular Function:CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; protein homodimerization activity Biological Process: cell-cell signaling; chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of T cell cytokine production; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of interleukin-10 production; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; regulation of inflammatory response; release of sequestered calcium ion into cytosol; response to virus |
| NCBI Summary: | mouse homolog is a cytokine with chemotactic activity for lymphocytes but not for monocytes or neutrophils [RGD, Feb 2006] |
| UniProt Code: | P51672 |
| NCBI GenInfo Identifier: | 19705461 |
| NCBI Gene ID: | 171371 |
| NCBI Accession: | NP_599188.1 |
| UniProt Related Accession: | P51672 |
| Molecular Weight: | 10.0 kDa |
| NCBI Full Name: | lymphotactin |
| NCBI Synonym Full Names: | X-C motif chemokine ligand 1 |
| NCBI Official Symbol: | Xcl1�� |
| NCBI Official Synonym Symbols: | Ltn; Scyc1�� |
| NCBI Protein Information: | lymphotactin |
| UniProt Protein Name: | Lymphotactin |
| UniProt Synonym Protein Names: | C motif chemokine 1; Cytokine SCM-1; Small-inducible cytokine C1 |
| Protein Family: | Lymphotactin |
| UniProt Gene Name: | Xcl1�� |
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