Enzymes Recombinant Proteins

Rat LCN2 Recombinant Protein (RPPB1892)

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SKU:
RPPB1892
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P30152
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat LCN2 Recombinant Protein
Product Code:RPPB1892
Size:10µg
Species:Rat
Target:LCN2
Synonyms:Neutrophil gelatinase-associated lipocalin, NGAL, Alpha-2-microglobulin-relatedprotein, Alpha-2U globulin-related protein, Lipocalin-2, Siderocalin LCN2, p25.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LCN2protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH7.4) and20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQDSTQNL IPAPPLISVP LQPGFWTERF QGRWFVVGLA ANAVQKERQSRFTMYSTIYE LQEDNSYNVT SILVRGQGCR YWIRTFVPSS RPGQFTLGNI HSYPQIQSYD VQVADTDYDQFAMVFFQKTS ENKQYFKVTL YGRTKGLSDE LKERFVSFAKSLGLKDNNIV FSVPTDQCID N

Lipocalin-2 also called Neutrophil Gelatinase Associated Lipocalin (NGAL) belongs to a family of lipocans which include 25 proteins (including a1-microglobulin and b-lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core.�They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke.

LCN2 Rat Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 201 amino acids (21-198 a.a) andhaving a molecular mass of 22.9kDa.LCN2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Apoptosis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function:protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to drug; response to nutrient levels; response to mycotoxin; response to virus; positive regulation of cell projection organization and biogenesis; response to herbicide; cellular response to nutrient levels; iron ion homeostasis; response to bacterium; siderophore transport; innate immune response; ion transport; response to oxidative stress

NCBI Summary:mouse homolog plays a role in IL3 withdrawal-induced apoptosis [RGD, Feb 2006]
UniProt Code:P30152
NCBI GenInfo Identifier:306526224
NCBI Gene ID:170496
NCBI Accession:P30152.2
UniProt Secondary Accession:P30152,Q5HZF1,
UniProt Related Accession:P30152
Molecular Weight:22,476 Da
NCBI Full Name:Neutrophil gelatinase-associated lipocalin
NCBI Synonym Full Names:lipocalin 2
NCBI Official Symbol:Lcn2��
NCBI Official Synonym Symbols:Sip24��
NCBI Protein Information:neutrophil gelatinase-associated lipocalin; p25; NGAL; lipocalin-2; siderocalin LCN2; lipocalin 2 (oncogene 24p3); alpha-2U globulin-related protein; alpha-2-microglobulin-related protein
UniProt Protein Name:Neutrophil gelatinase-associated lipocalin
UniProt Synonym Protein Names:Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin-2; Siderocalin LCN2; p25
Protein Family:Neutrophil gelatinase-associated lipocalin
UniProt Gene Name:Lcn2��
UniProt Entry Name:NGAL_RAT
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system_update_altDatasheetRat LCN2/NGAL Recombinant Protein Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin sup