Growth Factors & Cytokines Recombinant Proteins

Rat KGF 2 Recombinant Protein (RPPB0701)

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SKU:
RPPB0701
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P70492
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Rat KGF 2 Recombinant Protein
Product Code:RPPB0701
Size:25µg
Species:Rat
Target:KGF 2
Synonyms:FGFA, FGF10, FGF-10, KGF-2, Fibroblast growth factor 10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4 containing 5% trehalose.
Solubility:It is recommended to reconstitute the lyophilized KGF 2 Rat Recombinant in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized KGF 2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution KGF 2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:QALGQDMVSP EATNSSSSSS SSSSSSSFSS PSSAGRHVRS YNHLQGDVRW RKLFSFTKYF LKIEKNGKVS GTKKENCPYS ILEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA HFLPMVVHS
Biological Activity:Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is <0.5ng/ml.

KGF-2 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.

KGF 2 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 20.0kDa. The KGF 2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
NCBI Summary:binds the KGFR receptor, a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis [RGD, Feb 2006]
UniProt Code:P70492
NCBI GenInfo Identifier:6015143
NCBI Gene ID:25443
NCBI Accession:P70492.1
UniProt Related Accession:P70492
Molecular Weight:24,029 Da
NCBI Full Name:Fibroblast growth factor 10
NCBI Synonym Full Names:fibroblast growth factor 10
NCBI Official Symbol:Fgf10��
NCBI Official Synonym Symbols:FGF-10��
NCBI Protein Information:fibroblast growth factor 10
UniProt Protein Name:Fibroblast growth factor 10
Protein Family:Fibroblast growth factor
UniProt Gene Name:Fgf10��
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