Chemokines Recombinant Proteins

Rat IP 10 Recombinant Protein (RPPB1173)

(No reviews yet) Write a Review
SKU:
RPPB1173
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P48973
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat IP 10 Recombinant Protein
Product Code:RPPB1173
Size:25µg
Species:Rat
Target:IP 10
Synonyms:C-X-C motif chemokine 10, Gamma-IP10, IP-10, Protein Mob-1, Small-inducible cytokine B10, Cxcl10, Inp10, Mob1, Scyb10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized IP-10 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP
Biological Activity:Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

IP-10 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.6kDa.The IP-10 is purified by proprietary chromatographic techniques.

UniProt Protein Function:In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
NCBI Summary:induces DNA synthesis, cell proliferation, and cell migration in vascular smooth muscle cells; may play a role in vascular remodeling [RGD, Feb 2006]
UniProt Code:P48973
NCBI GenInfo Identifier:146345511
NCBI Gene ID:245920
NCBI Accession:P48973.2
UniProt Secondary Accession:P48973,P70538, Q6GTC7,
UniProt Related Accession:P48973
Molecular Weight:10,729 Da
NCBI Full Name:C-X-C motif chemokine 10
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 10
NCBI Official Symbol:Cxcl10��
NCBI Official Synonym Symbols:IP-10; Scyb10��
NCBI Protein Information:C-X-C motif chemokine 10; gamma-IP10; protein Mob-1; small-inducible cytokine B10; interferon-inducible protein 10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10
UniProt Protein Name:C-X-C motif chemokine 10
UniProt Synonym Protein Names:10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10
UniProt Gene Name:Cxcl10��
UniProt Entry Name:CXL10_RAT
View AllClose

0 Reviews

View AllClose

Related Products