Growth Factors & Cytokines Recombinant Proteins
Rat Interleukin-2/IL-2 Recombinant Protein (RPES4317)
- SKU:
- RPES4317
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Research Area:
- Growth Factors & Cytokines
Description
Rat Interleukin-2/IL-2 Recombinant Protein
Interleukin-2(IL-2)is a O-glycosylated four ?-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, ?? T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.
| Product Name: | Rat Interleukin-2/IL-2 Recombinant Protein (RPES4317) |
| Product Code: | RPES4317 |
| Size: | 10µg |
| Species: | Rat |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-2, IL-2, T-cell growth factor, TCGF, Aldesleukin, IL2 |
| Accession: | P17108 |
| Sequence: | Ala21-Gln155 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Rat Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Gln155 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 16.3 kDa |
| AP Mol Mass: | 14-16 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH4.0. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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