Cytokines Recombinant Proteins

Rat IL 7 Recombinant Protein (RPPB0544)

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SKU:
RPPB0544
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P56478
Research Area:
Cytokines

Description

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Product Name:Rat IL 7 Recombinant Protein
Product Code:RPPB0544
Size:10µg
Species:Rat
Target:IL 7
Synonyms:Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized�IL-7 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-7 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by SDS-PAGE.
Amino Acid Sequence:DCHIKDKDGK AFGSVLMISI NQLDKMTGTD SDCPNNEPNF FKKHLCDDTK EAAFLNRAAR KLRQFLKMNI SEEFNDHLLR VSDGTQTLVN CTSKEEKTIK EQKKNDPCFL KRLLREIKTC WNKILKGSI
Biological Activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2ng/ml, corresponding to a specific activity of >5,000,000IU/mg.

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

IL 7 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 15.0kDa.The IL 7 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
NCBI Summary:hematopoietic cytokine; involved in immune response and brain tumor growth [RGD, Feb 2006]
UniProt Code:P56478
NCBI GenInfo Identifier:3024010
NCBI Gene ID:
NCBI Accession:P56478.1
Molecular Weight:15.0 kDa
NCBI Full Name:Interleukin-7
UniProt Protein Name:Interleukin-7
Protein Family:Interleukin
UniProt Gene Name:Il7��
UniProt Entry Name:IL7_RAT
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