Growth Factors & Cytokines Recombinant Proteins
Rat IL-6/Interleukin-6 Recombinant Protein (RPES3914)
- SKU:
- RPES3914
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Research Area:
- Growth Factors & Cytokines
Description
Rat IL-6/Interleukin-6 Recombinant Protein
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Rat IL-6/Interleukin-6 Recombinant Protein (RPES3914) |
| Product Code: | RPES3914 |
| Size: | 20µg |
| Species: | Rat |
| Expressed Host: | E. coli |
| Synonyms: | IL6 |
| Accession: | NP_036721.1 |
| Sequence: | Phe25-Thr211 |
| Activity: | Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells.The ED50 for this effect is typically 1-6 ng/ml. |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the rat IL6 (Phe25-Thr211) was expressed and purified with an initial Met. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Mol Mass: | 21.9 kDa |
| AP Mol Mass: | 22 kDa |
| Formulation: | Lyophilized from sterile 40% acetonitrile, 0.1% TFA |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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